Protective role of neuregulin-1 toward doxorubicin-induced myocardial toxicity
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چکیده
منابع مشابه
Protective role of neuregulin-1 toward doxorubicin-induced myocardial toxicity.
The aim of this study was to investigate the role of the rat neuregulin-1 (NRG-1) protein in reducing doxorubicin (DOX)-induced myocardial toxicity and its underlying mechanism. The prokaryotic expression of the NRG-1 protein and the CCK8-determined activity of rat primary myocardial cells were evaluated under different DOX concentrations. Myocardial cells were divided into three groups: the co...
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Doxorubicin is Anrthacycline derivative and most active cytotoxic agent in current use. It is been using to treat various malignancies but the clinical usefulness has been limited due to its specific cardiac toxicity. The main objective is to study the preventive role of ethanolic extract of whole plant of Boerhaavia diffusa (EEBD) against doxorubicin (Dox) induced myocardial toxicity in rats. ...
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Neuregulin-1 (NRG1) is a potential therapeutic agent for the treatment of doxorubicin (Dox)-induced heart failure. NRG1, however, activates the erbB2 receptor, which is frequently overexpressed in breast cancers. It is, therefore, important to understand how NRG1, via erbB2, protects the heart against Dox cardiotoxicity. Here, we studied NRG1-erbB2 signaling in Dox-treated mice hearts and in is...
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BACKGROUND Young cancer patients may occasionally face infertility and premature gonadal failure. Apart from its direct effect on follicles and oocytes, chemotherapy may induce ovarian toxicity via an impact on the entire ovary. The role of doxorubicin in potential ovarian failure remains obscure. Our intention was to elucidate doxorubicin-related toxicity within ovaries. METHODS Female mice ...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2014
ISSN: 1676-5680
DOI: 10.4238/2014.june.18.5